Selected Chapters

  • Clare E. Thomas, Evelyn Abordo-Adesida, Tricia C. Maleniak, Daniel Stone, Christian A. Gerdes and Pedro R. Lowenstein.(2000) Gene Tranfer into Rat Brain Using Adenoviral Vectors. Current Protocols in Neuroscience, 4.24.1-4.24.36

  • Thomas D. Southgate, Paul A. Kingston, and Maria G. Castro(2000). Gene Transfer into Cells In Vitro Using Adenoviral Vectors. Current Protocols in Neuroscience, 4 .23.1-4.23.40. Click here for the PDF (7.47 MB)

  • Lowenstein, P.R., Stone, D., David, A., Thomas, C., Bataille, D. and Castro, M.G. Therapeutic applications of viral vectors for gene therapy. In Genetically Engineered Viruses. Ed. C Ring and E Blair, Bios Publishers, p. 215-254, 2001.

  • Castro, M.G., Hurtado-Lorenzo, A., Umana, P., Smith-Arica, J.R., Zermansky, A., Abordo-Adesida, E. and Lowenstein, P.R. Regulatable and cell-type specific transgene expression in glial cells: prospects for gene therapy for neurological disorders. In Progress in Brain Research, Elsevier Science Publishers, Vol. 132, 665-691, 2001 Click here for the PDF (5MB)

  • P.R. Lowenstein Ethical aspects of gene therapy, as applied to the treatment of neurological disorders. In A Companion to Genetics (Blackwell Companions to Philosophy). Editors: J Burley and J. Harris, Blackwell Publications, Oxford, UK, 2001.

  • Davis, A., Stone, D., Cowen, R.L., Castro, M.G. and Lowenstein, P.R. (2001) Transient transgenesis in the endocrine system: viral vectors for gene delivery: In: Transgenic Models in Endocrinology, (Maria G. Castro, Ed. ) Kluwer Academic Publishers, U.S.A. Chapter 10 pp195-232.

  • Castro, M.G., Williams, J.C., Southgate, T.D., Smith-Arica, J., Stone, D., Hurtado-Lorenzo, A., Umana, P. and Lowenstein, P.R. (2001) Cell type specific and inducible transgenesis in the anterior pituitary gland. In: Transgenic Models in Endocrinology, (Maria G. Castro, Ed.) Kluwer Acadmemic Publishers, U.S.A., Chapter 11, pp 223-256.

  • Hurtado-Lorenzo, A., et al. (2003). "Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions." Methods Mol Med 76: 113-33. Click here for the PDF (2.4MB)

  • Lowenstein P.R., Barcia C., Sciascia S., Candolfi M., Xiong W., Puntel M., Jacob A., Castro M.G., (2006) Gene Therapy: from visionary insights to clinical trials; a brain¿s eye view. Emery and Rimoin¿s Principles and Practice of Medical Genetics, 5th Edition, Elsevier, Inc., New York (In Press)

  • Lowenstein PR, Barcia-Gonzales C, Zirger J, Puntel M, Kroeger K, Xiong W, Kang T, Fakhouri T, Muhammad AKM, Liu C, Bergeron J, Johnson S, Castro MG, (2006) Immune Responses to Viral Vectors: Implications for Neurological Gene Therapy. Gene Therapy for Neurological Disorders Taylor & Francis Group, LLC. Edited by MG Castro, PR Lowenstein, p. 1-16. Click here for the PDF

  • Larocque D, Castro MG, Lowenstein PR, (2006) Gene Therapy of Multiple Sclerosis and in CNS autoimmune mouse models. Gene Therapy for Neurological Disorders Taylor & Francis Group, LLC. Edited by MG Castro, PR Lowenstein, p. 213-228.

  • Castro MG, Curtin JF, King GD, Candolfi M, Czer P, Kroeger K, Sciascia S, Xiong W, Fakhouri T, Honig S, Kuoy W, Kang T, Johnson S, Lowenstein PR, (2006) Novel Gene Therapeutic Approaches to Brain Cancer. Gene Therapy for Neurological Disorders Taylor & Francis Group, LLC. Edited by MG Castro, PR Lowenstein, p. 229-264.

  • Zirger J, Barcia C, Puntel M, Kroeger K, Xiong W, Kang T, Fakhouri T, Muhammad AKM, Liu C, Bergeron J, Johnson S, Castro MG, Lowenstein PR. Immune Responses To Viral Vectors: Implications For Neurological Gene Therapy. Gene Therapy for Neurological Disorders. M.G. Castro and P.R. Lowenstein, Editors. 2006, Taylor and Francis: New York. P. 1-11. Click here for the PDF

  • Castro MG, Curtin JF, King GD, Candolfi M, Czer P, Sciascia SA,.Kroeger KM, Fakhouri T, Honig S, Kuoy W, Kang T, Johnson S, Lowenstein PR. Novel Gene Therapeutic Approaches to Brain Cancer. Gene Therapy for Neurological Disorders. M.G. Castro and P.R. Lowenstein, Editors. 2006, Taylor and Francis: New York. p. 229-264. Click here for the PDF

  • Curtin JF, Candolfi M, Puntel M, Xiong W, Muhammad AKM, Kroeger KM, Liu C, Mondkar S, Bondale N, Lowenstein PR, Castro MG. Regulated expression of viral vectors-based gene therapies: therapeutic expression of toxins and immune-modulators. Gene Therapy Protocols; Volume 2: Design and Characterization of Gene Transfer Vectors; Methods in Molecular Biology, Vol. 434; LeDoux, Joseph (Ed.) 3rd ed., 2007 Humana Press. Click here for the PDF

  • Lowenstein PR, Kroeger KM, Barcia C, Zirger J, Larocque D, Castro MG. The neuroimmunology of gene therapy: addressing and overcoming immunological challenges in the use of viral vectors for the treatment of neurological disorders. Handbook of Neurochemistry & Molecular Neurobiology: Neuroimmunology. 3rd edition, Chapter 11, p263-281. Edited by Dr. Abel Lajtha. (2008; Springer Science; New York, NY. ISBN 978-0-387-30358-1).

  • Lowenstein PR, Kroeger KM, Castro MG, Friedman T. Gene Therapy for Central Nervous System Disorders. The Molecular and Genetic Basis of Neurological and Psychiatric Disease. 4th edition, Chapter 6. p87-103. Edited by Dr. Roger N. Rosenberg, MD. (2008; Lippincott Williams & Watkins; Philadelphia, PA. ISBN 978-0-7817-6956-3). Click here for the PDF

  • Lowenstein PR, Mandel RJ, Xiong W, Kroeger KM, Castro MG. Immune responses to adenovirual, AAV, and lentiviral vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions. Immunology of Gene Therapy. (Editor, Roland Herzog). (2007, In Press).

  • Lowenstein PR, Kroeger KM, Castro MG. Viral Gene Therapy for Central Nervous System Diseases. Neurotropic virus infections. (Editor ,Carol Shoshkes Reiss). (In Press, 2007).