Cardiovascular Gene Therapy
  • Guillot, C., Mathieu, P., Coathalem, H., Le Mauff, B., Castro, M.G., Tesson, L., Usal, C., Laumonier, T, Brouard, S., Soulillou J-P., Lowenstein, P.R., Cuturi, M.C. and Anegon I. Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression. Journal of Immunology, 164: 5258-5268, 2000. Click here for the PDF (.5MB)

  • Kingston, P.A., Sinha, S., Castro, M.G., Lowenstein, P.R., and Heagerty, A.M. Adenovirus-mediated gene transfer of a secreted TGF-B type II receptor inhibits luminal loss and constrictive remodeling post-PTCA. Circulation, 104: 2595-2601, 2001. Click here for the PDF (.4MB)

  • Guillot, C., Guillonneau, C., Mathieu, P., Gerdes, C.A., Menoret, S., Braudeau, Tesson, L., C., Renaudin, K., Benjamin, C., Castro, M.G., Lowenstein, P.R., Anegon, I. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor specific hypo responsiveness but does not prevent chronic rejection. Journal of Immunology, 168:1600-1609,2002. Click here for the PDF (.6)

  • Mathieu, P., C. Guillot, C. Gerdes, F. Buzelin, P. Lowenstein, M. Castro, J. P. Soulillou and I. Anegon (2002). "Adenovirus-mediated CD40Ig expression attenuates chronic vascular rejection lesions in an aorta allotransplantation model." Transplant Proc 34(3): 743-4. Click here for the PDF (.05MB)

  • Appleby, C. E., P. A. Kingston, A. David, C. A. Gerdes, P. Umana, M. G. Castro, P. R. Lowenstein and A. M. Heagerty (2003). "A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer." Gene Ther 10(18): 1616-22. Click here for the PDF(.2mb)

  • Guillot, C., S. Menoret, C. Guillonneau, C. Braudeau, M. G. Castro, P. Lowenstein and I. Anegon (2003). "Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig." Blood 101(8): 3325-33. Click here for the PDF(.3MB)

  • Kingston PA, Sinha S, Appleby CE, David A, Verakis T, Castro MG, Lowenstein PR, Heagerty AM."Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty." Circulation. 2003 Dec 2;108(22):2819-25. Epub 2003 Nov 24. Click here for the PDF (382 KB)